Hailing from Colorado, the Denver native grew up playing at Cherry Hills Country Club which has hosted three U.S. Opens (1938, 1960, 1978), two PGA Championships (1941, 1985), and a U.S. Women’s Open (2005).

Clark’s impressive amateur career includes two Colorado state high school titles won at Valor Christian, the same school that produced Christian McCaffrey, current San Francisco 49ers running back. Not only did Wyndham play on the school's basketball team with McCaffrey, but he also excelled in golf at Oklahoma State before transferring to the University of Oregon for the 2016-17 season. There, he won the Pac-12 Conference title and was deservedly named Golfweek magazine's Player of the Year.

Clark earned two wins on the PGA Tour in 2023 with his first in May at the Wells Fargo Championship, followed up a month later with his first major championship victory at the U.S. Open at Los Angeles Country Club. He went on to make his debut on the U.S. Ryder Cup team with a record of 1-1-1.